Could A Specific Probiotic Help You Absorb More Iron?

Tamika Woods 1 min read

Iron deficiency is one of the most common nutrient deficiencies worldwide, particularly in women of reproductive age. While many people focus on increasing the amount of iron they eat or supplement with, this research explored a different question: could improving the body's ability to absorb iron be just as important?

This paper reports the findings from two single-blind, placebo-controlled human clinical studies involving healthy menstruating women. Researchers used one of the gold standard methods for measuring iron absorption and compared the exact same meal with and without the specific probiotic strain Lactobacillus plantarum 299v.

Across two clinical studies, women absorbed up to 29% more iron from the same meal when they took the probiotic alongside it.

These findings suggest that supporting the gut can play an important role in helping the body make better use of the iron already present in food and supplements.

A quick note on the name: In 2020, Lactobacillus plantarum was reclassified as Lactiplantibacillus plantarum. Because much of the research was published before this change, you may see both names used interchangeably. They refer to the same probiotic species and strain, Lp299v.

Iron Absorption Matters Just As Much As Iron Intake

Many people assume that taking an iron supplement or eating more iron-rich foods is enough to improve iron status. However, the amount of iron you consume is only part of the equation. Your body must also be able to absorb and use that iron effectively.

Researchers have known for many years that iron absorption varies considerably between individuals. Factors such as gut health, inflammation, the foods eaten alongside iron, and the balance of bacteria in the digestive tract all influence how much iron is ultimately absorbed.

This study focused on one specific probiotic strain, Lp299v, to determine whether it could improve the body's ability to absorb iron from a meal.

How Was The Study Performed?

Researchers recruited healthy menstruating women with normal iron stores and compared iron absorption from identical meals consumed with and without Lp299v.

Using a sophisticated double-isotope technique, considered one of the gold standard methods for measuring iron absorption, they were able to accurately determine exactly how much iron entered the body after each meal.

The study was repeated twice in separate groups of women, allowing the researchers to confirm whether the findings were consistent.

What Did The Researchers Find?

The results were remarkably consistent across both studies.

Women absorbed up to 29% more iron from the exact same meal when it was consumed alongside Lp299v compared with the meal alone.

Importantly, nothing else about the meals changed. The women did not consume more iron. Instead, their bodies were simply able to absorb more of the iron that was already present.

This highlights an important concept: supporting iron absorption can be just as valuable as increasing iron intake.

How Does Lp299v Help Iron Absorption?

The exact mechanism is still being explored, but researchers believe Lp299v supports several processes that make iron easier for the body to absorb.

These include:

• Increasing the availability of iron within the digestive tract

• Creating an environment that favours iron absorption

• Supporting the health and function of the intestinal lining

• Positively influencing the gut microbiome

Rather than supplying iron itself, Lp299v appears to help the body utilise dietary iron more efficiently.

Why This Matters For Women

Iron deficiency remains one of the most common nutritional deficiencies worldwide, particularly in menstruating women.

Low iron stores can contribute to symptoms such as:

• Fatigue

• Reduced energy

• Poor concentration

• Weakness

• Reduced exercise capacity

• Hair shedding

Improving iron absorption offers another strategy to support healthy iron levels, alongside consuming adequate dietary iron and using well-formulated supplements where appropriate.

What Does This Mean For Women With PCOS/PMOS?

Although this study was not conducted specifically in women with PCOS/PMOS, the findings are still highly relevant.

Many women with PCOS/PMOS experience low iron or depleted iron stores. For some, this relates to heavy or prolonged menstrual bleeding. For others, pregnancy, postpartum recovery, restrictive eating patterns, or poor iron absorption may contribute.

Low iron can also worsen symptoms that overlap with PCOS/PMOS, including fatigue, low energy, poor concentration and hair shedding. This means iron status is an important part of the bigger health picture and should not be overlooked.

One thing I really appreciated about this research is that it reminds us that supporting iron levels is not always just about taking more iron. Sometimes, it is also about helping your body absorb the iron you are already consuming.

While this study was not conducted specifically in women with PCOS/PMOS, I think the findings are still incredibly relevant. Throughout my years in clinic, I have seen many women with PCOS/PMOS struggle with low iron or depleted iron stores. For some, this is related to heavy or prolonged periods. For others, it can be pregnancy, postpartum recovery, restrictive dieting, or simply not absorbing enough iron from food or supplements.

Low iron can also add another layer to symptoms that are already common in PCOS/PMOS, including fatigue, low energy, poor concentration, hair shedding, weakness and reduced exercise tolerance. This is one of the reasons it is so important not to assume that every symptom is being caused by hormones alone.

That is why I have always believed we need to think beyond simply increasing the dose of iron. Supporting the gut, choosing a highly bioavailable form of iron, and considering the factors that influence absorption can all make a meaningful difference.

This research is one of the reasons I was so excited to reformulate our ProbIron. It combines gentle, highly bioavailable iron bisglycinate with the clinically researched probiotic strain Lactiplantibacillus plantarum 299v, the same strain investigated in this study, to support both iron intake and absorption. We also included vitamin C and copper to further support healthy iron metabolism.

If you have struggled to maintain healthy iron levels, experienced digestive discomfort from traditional iron supplements, or feel that fatigue or hair shedding may be part of the picture, our newly reformulated ProbIron provides a more comprehensive and evidence-based approach to iron support.

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Tamika Woods

About Tamika Woods

Tamika Woods is a Clinical Nutritionist and bestselling author of PCOS Repair Protocol. She holds a Bachelor of Health Science (Nutritional Medicine) from Endeavour College of Natural Health and a Bachelor of Education from UNSW, graduating with Honours in both.

She is a certified Fertility Awareness Method Educator and ANTA member, and the recipient of the ANTA Graduate Award. After a decade managing her own PCOS, Tam now helps women find hormonal balance through evidence-based protocols.

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