Did you know that at least 80% of women with PCOS have insulin resistance?
According to the CDC, insulin resistance is a major contributor to the symptoms of PCOS.
In women with PCOS who are overweight, the chances of having insulin resistance increases to 90%.
Luckily, diet and lifestyle changes to support blood sugar balance and improve insulin sensitivity are highly successful in reversing the symptoms of Insulin Resistant PCOS.
Weâve specifically curated this bundle for Insulin Resistant PCOS to naturally support your body to improve insulin sensitivity and support a reduction in PCOS symptoms.
How does this bundle address the root cause of Insulin Resistant PCOS?
The vitamins included in this power pack help your body to naturally keep blood sugar levels stable, reduce sugar cravings, improve energy levels and support healthy body weight.
Alongside positive lifestyle changes, hundreds of women have enjoyed significant benefits from this vitamin combination.
References (For The Nerds Like Us đ€)
âđ Xu Y, Qiao J. Association of Insulin Resistance and Elevated Androgen Levels with Polycystic Ovarian Syndrome (PCOS): A Review of Literature. J Healthc Eng. 2022 Mar 21;2022:9240569. doi: 10.1155/2022/9240569. PMID: 35356614; PMCID: PMC8959968.
ââđ Grant P, Ramasamy S. An update on plant derived anti-androgens. Int J Endocrinol Metab. 2012 Spring;10(2):497-502. doi: 10.5812/ijem.3644. Epub 2012 Apr 20. PMID: 23843810; PMCID: PMC3693613.
ââđ Stamatiadis D, Bulteau-Portois MC, Mowszowicz I. Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. Br J Dermatol. 1988 Nov;119(5):627-32. doi: 10.1111/j.1365-2133.1988.tb03474.x. PMID: 3207614.
ââđ Fujita R, Liu J, Shimizu K, Konishi F, Noda K, Kumamoto S, Ueda C, Tajiri H, Kaneko S, Suimi Y, Kondo R. Anti-androgenic activities of Ganoderma lucidum. J Ethnopharmacol. 2005 Oct 31;102(1):107-12. doi: 10.1016/j.jep.2005.05.041. PMID: 16029938.
ââđ Jamilian M, Foroozanfard F, Bahmani F, Talaee R, Monavari M, Asemi Z. Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. Biol Trace Elem Res. 2016 Apr;170(2):271-8. doi: 10.1007/s12011-015-0480-7. Epub 2015 Aug 28. PMID: 26315303.
ââđ Arentz, S., Abbott, J. A., Smith, C. A., & Bensoussan, A. (2014). Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings. BMC Complementary and Alternative Medicine,14(Article number: 511). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528347/
ââđ Arentz, S., Smith, C. A., Abbott, J., & Bensoussan, A. (2017). Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis. BMC Complementary and Alternative Medicine,17(Article number: 500). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895349/
ââđ Ashkar, F., Rezaei, S., Salahshoornezhad, S., Vahid, F., Gholamalizadeh, M., Dahka, S. M., & Doaei, S. (2020). The Role of medicinal herbs in treatment of insulin resistance in patients with Polycystic Ovary Syndrome: A literature review. Biomolecular Concepts, 11(1), 57-75. https://pubmed.ncbi.nlm.nih.gov/32229652/
ââđ Evron E, Juhasz M, Babadjouni A, Mesinkovska NA. Natural Hair Supplement: Friend or Foe? Saw Palmetto, a Systematic Review in Alopecia. Skin Appendage Disord. 2020 Nov;6(6):329-337. doi: 10.1159/000509905. Epub 2020 Aug 23. PMID: 33313047; PMCID: PMC7706486.
ââđ Dhariwala MY, Ravikumar P. An overview of herbal alternatives in androgenetic alopecia. J Cosmet Dermatol. 2019 Aug;18(4):966-975. doi: 10.1111/jocd.12930. Epub 2019 Apr 13. PMID: 30980598.
ââđ Rahmati M, Keshvari M, Mirnasouri R, Chehelcheraghi F. Exercise and Urtica dioica extract ameliorate hippocampal insulin signaling, oxidative stress, neuroinflammation, and cognitive function in STZ-induced diabetic rats. Biomed Pharmacother. 2021 Jul;139:111577. doi: 10.1016/j.biopha.2021.111577. Epub 2021 Apr 8. PMID: 33839493.
ââđ Fan S, Raychaudhuri S, Kraus O, Shahinozzaman M, Lofti L, Obanda DN. Urtica dioica Whole Vegetable as a Functional Food Targeting Fat Accumulation and Insulin Resistance-a Preliminary Study in a Mouse Pre-Diabetic Model. Nutrients. 2020 Apr 10;12(4):1059. doi: 10.3390/nu12041059. PMID: 32290353; PMCID: PMC7231388.
ââđ Kou L, Du M, Liu P, Zhang B, Zhang Y, Yang P, Shang M, Wang X. Anti-Diabetic and Anti-Nephritic Activities of Grifola frondosa Mycelium Polysaccharides in Diet-Streptozotocin-Induced Diabetic Rats Via Modulation on Oxidative Stress. Appl Biochem Biotechnol. 2019 Jan;187(1):310-322. doi: 10.1007/s12010-018-2803-6. Epub 2018 Jun 26. PMID: 29943275.
ââđPreuss HG, Echard B, Bagchi D, Perricone NV, Zhuang C. Enhanced insulin-hypoglycemic activity in rats consuming a specific glycoprotein extracted from maitake mushroom. Mol Cell Biochem. 2007 Dec;306(1-2):105-13. doi: 10.1007/s11010-007-9559-6. Epub 2007 Aug 1. PMID: 17671829.
ââđ Konno S. (2020). SX-fraction: Promise for novel treatment of type 2 diabetes. World journal of diabetes, 11(12), 572â583. https://doi.org/10.4239/wjd.v11.i12.572
đ Arentz, S., Abbott, J. A., Smith, C. A., & Bensoussan, A. (2014). Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings. BMC Complementary and Alternative Medicine,14(Article number: 511). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528347/
đ Arentz, S., Smith, C. A., Abbott, J., & Bensoussan, A. (2017). Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis. BMC Complementary and Alternative Medicine,17(Article number: 500). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895349/
đ Ashkar, F., Rezaei, S., Salahshoornezhad, S., Vahid, F., Gholamalizadeh, M., Dahka, S. M., & Doaei, S. (2020). The Role of medicinal herbs in treatment of insulin resistance in patients with Polycystic Ovary Syndrome: A literature review. Biomolecular Concepts, 11(1), 57-75. https://pubmed.ncbi.nlm.nih.gov/32229652/
đGoyal M, Dawood AS. Debates Regarding Lean Patients with Polycystic Ovary Syndrome: A Narrative Review. J Hum Reprod Sci. 2017 Jul-Sep;10(3):154-161. doi: 10.4103/jhrs.JHRS_77_17. PMID: 29142442; PMCID: PMC5672719.
đ Kalani, A., Bahtiyar, G., & Sacerdote, A. (2012). Ashwagandha root in the treatment of non-classical adrenal hyperplasia. BMJ Case Reports, 2012. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543599/
đ Langade, L., Kanchi, S., Salve, S., Debnath, K., & Ambegaokar, D. (2019). Efficacy and safety of ashwagandha (Withania somnifera) root extract in insomnia and anxiety: A double-blind, randomized, placebo-controlled study. Cureus, 11(9). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827862/
đ Lopresti, A. L., Smith, S. J., Malvi, H., &l Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract. A randomized, double-blind, placebo-controlled study. Medicine (Baltimore), 98(37). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750292/
đ Salve, J., Pate, S., Debnath, K., & Langade, D. (2019). Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study. Cureus, 11(12). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979308/
âđ Nestler, J.E.; Unfer, V. Reflections on Inositol(s) for PCOS Therapy: Steps toward Success. Gynecol. Endocrinol. 2015, 31, 501â505
âđ Facchinetti, F.; OrrĂč, B.; Grandi, G.; Unfer, V. Short-Term Effects of M**tformin and Myo-Inositol in Women with Polycystic Ovarian Syndrome (PCOS): A Meta-Analysis of Randomized Clinical Trials. Facchinetti F1, OrrĂč B2, Grandi G1, Unfer V3. Gynecol. Endocrinol. 2019, 35, 198â206
âđ LaganĂ , A.S.; Rossetti, P.; Buscema, M.; La Vignera, S.; Condorelli, R.A.; Gullo, G.; Granese, R.; Triolo, O. Metabolism and Ovarian Function in PCOSWomen: ATherapeutic Approach with Inositols. Int. J. Endocrinol. 2016, 2016, 6306410.
âđ Unfer V, Carlomagno G, Papaleo E, Vailati S, Candiani M, Baillargeon JP. Hyperinsulinemia Alters Myoinositol to d-chiroinositol Ratio in the Follicular Fluid of Patients With PCOS. Reprod Sci. 2014;21(7):854-8.
âđ Unfer, V.; Facchinetti, F.; OrrĂč, B.; Giordani, B.; Nestler, J. Myo-Inositol Effects in Women with PCOS: A Meta-Analysis of Randomized Controlled Trials. Endocr. Connect. 2017, 6, 647â658.
âđ Benelli, E.; Del Ghianda, S.; Di Cosmo, C.; Tonacchera, M. A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women. Int. J. Endocrinol. 2016, 2016, 3204083
â
âđ Bevilacqua, A.; Carlomagno, G.; Gerli, S.; Oliva, M.M.; Devroey, P.; Lanzone, A.; Soulange, C.; Facchinetti, F.; Di Renzo, G.C.; Bizzarri, M.; et al. Results from the International Consensus Conference on Myo-Inositol and D-Chiro-Inositol in Obstetrics and Gynecology-Assisted Reproduction Technology. Gynecol. Endocrinol. 2015, 31, 441â446.
âđ Colazingari, S.; Treglia, M.; Najjar, R.; Bevilacqua, A. The Combined Therapy Myo-Inositol plus D-Chiro-Inositol, Rather than D-Chiro-Inositol, Is Able to Improve IVF Outcomes: Results froma Randomized Controlled Trial. Arch. Gynecol. Obstet. 2013, 288, 1405â1411.
âđ Ravanos K, Monastra G, Pavlidou T, Goudakou M, Prapas N. Can high levels of D-chiro-inositol in follicular fluid exert detrimental effects on blastocyst quality? European review for medical and pharmacological sciences. 2017;21(23):5491-8.
âđ Dinicola, S.; Chiu, T.T.Y.; Unfer, V.; Carlomagno, G.; Bizzarri, M. The Rationale of the Myo-Inositol and D-Chiro-Inositol Combined Treatment for Polycystic Ovary Syndrome. J. Clin. Pharmacol. 2014, 54, 1079â1092
âđ Bevilacqua, A.; Dragotto, J.; Giuliani, A.; Bizzarri, M. Myo-Inositol and D-Chiro-Inositol (40:1) Reverse
Histological and Functional Features of Polycystic Ovary Syndrome in a Mouse Model. J. Cell. Physiol. 2019,
234, 9387â9398.
âđ Diamanti-Kandarakis, E.; Dunaif, A. Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications. Endocr. Rev. 2012, 33, 981â1030.
âđ Abdel Hamid AMS, Ismail Madkour WA, Borg TF. Inositol versus M*****min administration in polycystic ovary syndrome patients: a caseâcontrol study. Journal of Evidence-Based Womenâs Health Journal Society. 2015;5(3). https://journals.lww.com/ebjwh/Fulltext/2015/08000/Inositol_versus_***_administration_in.2.aspx
